PAAD-2 (Physical Activity and Alzheimer’s Disease) - Greensboro, NC


  • Location:
  • Age: 40 to 65
  • Duration: 12-16 months
  • Visits: Up to 6
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Eligibility Requirements

UNCG researchers are looking for people who:

  • are between 40-65 years old
  • have a family history of Alzheimer’s disease or dementia
  • can travel to Greensboro for data collection visits for 2 days at beginning of study, after 6 months, and after 1 year
  • are not regularly physically active (exercise less than 90min/week)
  • are not displaying symptoms of memory or thinking impairment or depression
  • are not taking medications that affect thinking or exercise
  • are healthy enough to exercise at moderate intensity
  • do not have uncorrected visual or hearing impairment

About the Study:

Physical Activity and Alzheimer’s Disease - 2 (PAAD-2) is designed to test the effects of a 1-year virtual exercise program on the cognitive performance of adults relative to their risk for Alzheimer’s disease.


Results from this study may help researchers to understand the benefits of physical activity for persons with a family history of Alzheimer’s disease (AD) relative to a person's genetic risk for AD.

What is Involved:

Participants will be asked to complete up to 6 in-person data collection visits over 12-16 months. During data collection visits, participants will answer questions about their health, perform cognitive tests, and complete an aerobic fitness test. 

Participants will also be asked to provide a blood sample and a saliva sample for APOE genotyping. If a participant can safely complete an MRI scan, they will be asked to do so. 

After completing pre-testing, participants will be randomly assigned to either a 12-month virtual exercise program (exercise group) or asked to maintain their current level of physical activity for 12 months (control group). The control group will receive a free short-term membership to their local YMCA (or cash equivalent) upon study completion. 

All participants will be compensated for data collection visits.

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