Study

PAAD-2 (Physical Activity and Alzheimer’s Disease) - Greensboro, NC

Eligibility Requirements:

UNCG researchers are looking for people who:

  • are between 40-65 years old
  • have a family history of Alzheimer’s disease or dementia
  • can travel to Greensboro for data collection visits for 2 days at beginning of study, after 6 months, and after 1 year
  • are not regularly physically active (exercise less than 90min/week)
  • are not displaying symptoms of memory or thinking impairment or depression
  • are not taking medications that affect thinking or exercise
  • are healthy enough to exercise at moderate intensity
  • do not have uncorrected visual or hearing impairment

About the Study:

Physical Activity and Alzheimer’s Disease - 2 (PAAD-2) is designed to test the effects of a 1-year virtual exercise program on the cognitive performance of adults relative to their risk for Alzheimer’s disease.

Purpose:

Results from this study may help researchers to understand the benefits of physical activity for persons with a family history of Alzheimer’s disease (AD) relative to a person's genetic risk for AD.

What is Involved:

Participants will be asked to complete up to 6 in-person data collection visits over 12-16 months. During data collection visits, participants will answer questions about their health, perform cognitive tests, and complete an aerobic fitness test. 


Participants will also be asked to provide a blood sample and a saliva sample for APOE genotyping. If a participant can safely complete an MRI scan, they will be asked to do so. 


After completing pre-testing, participants will be randomly assigned to either a 12-month virtual exercise program (exercise group) or asked to maintain their current level of physical activity for 12 months (control group). The control group will receive a free short-term membership to their local YMCA (or cash equivalent) upon study completion. 


All participants will be compensated for data collection visits.

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Age:
40 to 65
Duration:
12-16 months
Visits:
Up to 6
Study Type:
Observational Studies; Prevention Studies; Studies for People without Memory Impairment

Study Site Locations: