You may be eligible for TRC-DS if you meet the following criteria:
Exceptions to these guidelines may be considered on a case-by-case basis at the discretion of the Project Director.
Alzheimer’s disease (AD) is the primary cause of death in adults with Down syndrome (DS) over the age of 35, highlighting the pressing need for the inclusion of individuals with DS in clinical trials for AD. The Trial- Ready Cohort- Down Syndrome (TRC-DS) focuses on adults with DS TRC-DS matches people with DS to AD clinical trials specifically designed for people with DS. Volunteers become part of a community of clinical trial volunteers who can help find a cure for Alzheimer’s. TRC-DS routinely monitors volunteers for any changes to their brain health or function over time through blood tests and brain imaging to eventually match them with applicable AD clinical trials. Through routine screenings, researchers can fast-track TRC-DS volunteers for enrollment in qualifying clinical studies as soon as they are eligible and matched with one.
The purpose of TRC-DS is to enroll 120 non-demented adults with DS (ages 35-55) across 15 sites to determine longitudinal cognitive, clinical and biomarker trajectories in the cohort and accelerate enrollment into clinical trials. People with DS helped researchers discover the genetic connection between chromosome 21, amyloid and AD almost 40 years ago. Researchers want to bring the latest therapies to people with DS who helped early Alzheimer’s research discoveries. TRC-DS is recruiting younger individuals because people with DS develop Alzheimer’s much earlier than others who develop the disease. If research could uncover ways to slow or prevent the progression of AD in people with DS, especially at an earlier age, it could also show how to target AD in others.
If you meet the inclusion criteria for the study, as discussed with your closest research site, the study entails 3 visits: screening, baseline, and month 16.