HOSTED BY BANNER ALZHEIMER'S INSTITUTE
660 South Euclid Avenue
St. Louis MO 63110
United States
If interested, please contact Cristina Toedebusch at 314-747-0646 or toedebuschc@wustl.edu
Participants cannot have:
There is evidence in mice that improving sleep may prevent changes seen in the brain associated with Alzheimer’s disease. The objective of this study is to translate these findings to humans for the long term improvement in human health.
The purpose of the study is to find out if differences in sleep quality will result in changes to amyloid-beta concentration in the fluid surrounding the brain called cerebrospinal fluid or CSF.
Participation in this study will require outpatient screening in addition to a 3 day/2 night stay at the clinical research unit. Participants will be randomized to either take placebo or a sleep aid at bedtime on both nights. A lumbar catheter (similar to a spinal tap or an epidural given at childbirth) will be in place for 36 hours and CSF will be drawn from the catheter every 2 hours. Wires will be applied to the scalp and face to monitor sleep/wake cycles.
Washington University School of Medicine
660 South Euclid Avenue
St. Louis MO 63110
United States
If interested, please contact Cristina Toedebusch at 314-747-0646 or toedebuschc@wustl.edu