Generation Program - Multiple Sites

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Generation Program - Multiple Sites

Eligibility Requirements

To qualify for the Generation Program, you need to meet the following requirements:

  • 60 to 75 years of age
  • Normal memory and thinking ability
  • 1 or 2 copies of the APOE e4 gene
  • Have a study partner willing to attend necessary study visits

About The Study:

The Generation Program is made up of two clinical trials: Generation Study 1 and Generation Study 2.

  • Each study will last for 5 – 8 years and test investigational Alzheimer’s products, which aim to prevent the onset of the disease.
  • To test our investigational medications, we’re asking thousands of people like you to help us. 
  • We’re not looking for people with Alzheimer’s, but rather those with a specific gene that can increase the risk of developing the disease. It is your genes that will determine whether you are eligible to take part in either of these studies.


The goal of the Generation Program is to find out whether experimental medications can prevent the onset of Alzheimer’s symptoms. In these clinical trials, we’ll test the study medications against placebo.

Research shows a link between a substance called amyloid beta and Alzheimer’s disease. The study medications may stop amyloid beta from building up in the brain.

Participants in this program could advance doctors’ understanding of how to potentially prevent the onset of Alzheimer’s.

What Is Involved:

Step 1 – Eligibility

To qualify for the program you must:

  • Be aged 60‐75
  • Have not been diagnosed with memory impairment

Step 2 – Genetic testing

We need to know whether you have the genetic marker before you can be enrolled. This requires a quick and simple cheek swab test that can be completed through the mail by joining the GeneMatch Program.

GeneMatch, led by the Banner Alzheimer’s Institute, uses genetic testing (through no cost cheek swab kits) to match volunteers with research opportunities like the Generation Program.

  • If you’re eligible for GeneMatch, you’ll receive a genetic test kit (at no cost to you), take a cheek swab sample, and send it back to the lab.
  • GeneMatch will contact you if you qualify for the screening phase of the Generation Program. Please note that you will not learn your genetic test results through GeneMatch.
  • Not everyone contacted by GeneMatch about the Generation Program screening has 1 or 2 copies of APOE e4.

If you are invited back to learn your genetic test results this does not mean you have the marker. You can refuse to hear your results if you no longer wish to take part, and before finding out your results you’ll be able to speak to a genetic counselor.

Only people with the genetic marker can take part in the Generation Program. Again, you can refuse an invitation at any point. This is an entirely voluntary process and we appreciate any time you give.

Do you already know that you have 1 or 2 copies of the APOE e4 gene? Contact us at or 1‐888‐STOP‐ALZ (1‐888‐786‐7259).

Step 3 – Participate in the Generation Program

If you’re eligible for the Generation Program, the study will run for between 5 and 8 years.

You’ll be given an investigational study drug, or a placebo. A placebo is an inactive form of the drug, which is vital to ensure the reliability of the results. During the study, you’ll need to visit a study site at regular intervals so we can run tests to measure the safety and potential effectiveness of the products.


  • 5 ‐ 8 year clinical trial for Alzheimer’s prevention
  • You’ll receive an investigational study medication or a placebo, at no cost
  • Regular study site visits (8 in first year, 4 visits a year thereafter)
  • Completely voluntary, you can leave at any time

Generation Program - Albuquerque - Now Enrolling!

Albuquerque, NM 87109, US
Albuquerque Neuroscience, Inc.

Generation Program - Atlanta - Emory University - Now Enrolling!

Atlanta, GA 30329, US
Emory University

Generation Program - Atlantis - JEM Research Institute - Now Enrolling!

Atlantis, FL 33462, US
JEM Research Institute

Generation Program - Austin, TX - Now Enrolling!

Austin, TX 78757, US
Senior Adults Specialty Research

Generation Program - Baltimore/Columbia - Coming Soon!

Baltimore/Columbia, MD 21227, US

Generation Program - Basalt - Now Enrolling!

Basalt, CO 81621, US
Roaring Fork Neurology

Generation Program - Beachwood - Now Enrolling!

Beachwood, OH 44122, US
University Hospitals Cleveland Medical Center

Generation Program - Bennington - Now Enrolling!

Bennington, VT 05201, US
The Memory Clinic

Generation Program - Charleston - Now Enrolling!

Charleston, SC 29401, US
Roper St. Francis Hospital

Generation Program - Charlotte - Now Enrolling!

Charlotte, NC 28270, US
ANI Neurology - The Alzheimer's Memory Center

Generation Program - Chicago - Great Lakes CT - Now Enrolling!

Chicago, IL 60640, US
Great Lakes Clinical Trials

Generation Program - Chicago - Rush - Now Enrolling!

Chicago, IL 60612, US
Rush University Medical Center - Rush Alzheimer's Disease Center

Generation Program - Colorado Springs - Now Enrolling!

Colorado Springs, CO 80907, US
Colorado Springs Neurological Associates

Generation Program - Columbus - Now Enrolling!

Columbus, GA 31909, US
Medical Research & Health Foundation, INC

Generation Program - Costa Mesa - Now Enrolling!

Costa Mesa, CA 92626, US
ATP Clinical Research Center

Generation Program - Decatur - Now Enrolling!

Decatur, GA 30033, US, LLC

Generation Program - Deerfield Beach - Quantam Laboratories - Now Enrolling!

Deerfield Beach, FL 33064, US
Quantam Laboratories - Memory Center

Generation Program - Delray Beach - Now Enrolling!

Delray Beach, FL 33445, US
Brain Matters Research

Generation Program - Denver - Now Enrolling!

Denver, CO 80210, US
Denver Neurological Research

Generation Program - Durham - Now Enrolling!

Durham, NC 27705, US
Duke University

Generation Program - East Providence - Now Enrolling!

East Providence, RI 02914, US
Rhode Island Mood and Memory Research Institute

Generation Program - Eatontown - Now Enrolling!

Eatontown, NJ 07724, US
Memory Enhancement Center

Generation Program - Elk Grove Village - Now Enrolling!

Elk Grove Village, IL 60007, US
Alexian Brothers Medical Center

Generation Program - Fairway - Now Enrolling!

Fairway, KS 66205, US
University of Kansas Medical Center Research Institute

Generation Program - Farmington Hills - Now Enrolling!

Farmington Hills, MI 48334, US
QUEST Research Institute

Generation Program - Greensboro - Now Enrolling!

Greensboro, NC 27410, US
Triad Clinical Trials

Generation Program - Hattiesburg - Now Enrolling!

Hattiesburg, MS 39401, US
Hattiesburg Clinic

Generation Program - Hollywood - Now Enrolling

Hollywood, FL 33024, US
Infinity Clinical Research LLC - Hollywood

Generation Program - Honolulu - Now Enrolling!

Honolulu, HI 96817, US
Hawaii Pacific Neuroscience

Generation Program - Houston - Clinical Trial Network - Now Enrolling!

Houston, TX 77074, US
Clinical Trial Network