Generation Program - Multiple Sites

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Generation Program - Multiple Sites

Study Status:
60 to 75
5-8 years
Study Type:
Prevention Studies
Studies for People without Memory Impairment

Eligibility Requirements:

To qualify for the Generation Program, you need to meet the following requirements:

  • 60 to 75 years of age
  • Normal memory and thinking ability
  • 1 or 2 copies of the APOE e4 gene
  • Have a study partner willing to attend necessary study visits

About the Study:

The Generation Program is made up of two clinical trials: Generation Study 1 and Generation Study 2.

  • Each study will last for 5 – 8 years and test investigational Alzheimer’s products, which aim to prevent the onset of the disease.
  • To test our investigational medications, we’re asking thousands of people like you to help us. 
  • We’re not looking for people with Alzheimer’s, but rather those with a specific gene that can increase the risk of developing the disease. It is your genes that will determine whether you are eligible to take part in either of these studies.


The goal of the Generation Program is to find out whether experimental medications can prevent the onset of Alzheimer’s symptoms. In these clinical trials, we’ll test the study medications against placebo.

Research shows a link between a substance called amyloid beta and Alzheimer’s disease. The study medications may stop amyloid beta from building up in the brain.

Participants in this program could advance doctors’ understanding of how to potentially prevent the onset of Alzheimer’s.

What is Involved:

Step 1 – Eligibility

To qualify for the program you must:

  • Be aged 60‐75
  • Have not been diagnosed with memory impairment
  • Have a study partner who can attend study visits with you

Step 2 – Genetic testing

We need to know whether you have the genetic marker before you can be enrolled. This requires a quick and simple cheek swab test that can be completed through the mail by joining the GeneMatch Program.

GeneMatch, led by the Banner Alzheimer’s Institute, uses genetic testing (through no cost cheek swab kits) to match volunteers with research opportunities like the Generation Program.

  • If you’re eligible for GeneMatch, you’ll receive a genetic test kit (at no cost to you), take a cheek swab sample, and send it back to the lab.
  • GeneMatch will contact you if you qualify for the screening phase of the Generation Program. Please note that you will not learn your genetic test results through GeneMatch.
  • Not everyone contacted by GeneMatch about the Generation Program screening has 1 or 2 copies of APOE e4.

If you are invited back to learn your genetic test results this does not mean you have the marker. You can refuse to hear your results if you no longer wish to take part, and before finding out your results you’ll be able to speak to a genetic counselor.

Only people with the genetic marker can take part in the Generation Program. Again, you can refuse an invitation at any point. This is an entirely voluntary process and we appreciate any time you give.

Do you already know that you have 1 or 2 copies of the APOE e4 gene? Contact us at or 1‐888‐STOP‐ALZ (1‐888‐786‐7259).

Step 3 – Participate in the Generation Program

If you’re eligible for the Generation Program, the study will run for between 5 and 8 years.

You’ll be given an investigational study drug, or a placebo. A placebo is an inactive form of the drug, which is vital to ensure the reliability of the results. During the study, you’ll need to visit a study site at regular intervals so we can run tests to measure the safety and potential effectiveness of the products.


  • 5 ‐ 8 year clinical trial for Alzheimer’s prevention
  • You’ll receive an investigational study medication or a placebo, at no cost
  • Regular study site visits (8 in first year, 4 visits a year thereafter)
  • Completely voluntary, you can leave at any time

United States

Generation Program - Albuquerque - Albuquerque Neuroscience, Inc.

Albuquerque, NM 87109, United States
Albuquerque Neuroscience, Inc.

Generation Program - Atlanta - Emory University - Emory University

Atlanta, GA 30329, United States
Emory University

Generation Program - Atlantis - JEM Research Institute

Atlantis, FL 33462, United States
JEM Research Institute

Generation Program - Austin - Senior Adults Specialty Research

Austin, TX 78757, United States
Senior Adults Specialty Research

Generation Program - Bangor - Acadia Hospital

Bangor, ME 04401, United States
Acadia Hospital

Generation Program - Basalt - Roaring Fork Neurology

Basalt, CO 81621, United States
Roaring Fork Neurology

Generation Program - Beachwood - University Hospitals Cleveland Medical Center

Beachwood, OH 44122, United States
University Hospitals Cleveland Medical Center

Generation Program - Bennington - The Memory Clinic

Bennington, VT 05201, United States
The Memory Clinic

Generation Program - Boca Raton - Florida Atlantic University

Boca Raton, FL 33431, United States
Florida Atlantic University

Generation Program - Boston - Beth Israel Deaconess Medical Center

Boston, MA 02115, United States
Beth Israel Deaconess Medical Center

Generation Program - Boston - Boston University Alzheimer's Disease Center

Boston, MA 02118, United States
Boston University - Alzheimer's Disease Center

Generation Program - Boston - Brigham and Women's Hospital

Boston, MA 02115, United States
Brigham and Women's Hospital

Generation Program - Centerville - Dayton Center for Neurological Disorders

Centerville, OH 45459, United States
Dayton Center for Neurological Disorders

Generation Program - Charleston - Roper St. Francis Hospital

Charleston, SC 29401, United States
Roper St. Francis Hospital

Generation Program - Charlotte - ANI Neurology - The Alzheimer's Memory Center

Charlotte, NC 28270, United States
ANI Neurology - The Alzheimer's Memory Center

Generation Program - Chicago - Great Lakes Clinical Trials

Chicago, IL 60640, United States
Great Lakes Clinical Trials

Generation Program - Chicago - Rush University Medical Center

Chicago, IL 60612, United States
Rush University Medical Center - Rush Alzheimer's Disease Center

Generation Program - Cincinnati - New Horizons Clinical Research

Cincinnati, OH 45242, United States
New Horizons Clinical Research

Generation Program - Columbus - Medical Research & Health Foundation, INC

Columbus, GA 31909, United States
Medical Research & Health Foundation, INC

Generation Program - Columbus - The Ohio State University

Columbus, OH 43210, United States
The Ohio State University

Generation Program - Costa Mesa - ATP Clinical Research Center

Costa Mesa, CA 92626, United States
ATP Clinical Research Center

Generation Program - Dallas - Kerwin Research Center, LLC

Dallas, TX 75231, United States
Kerwin Research Center, LLC

Generation Program - Decatur -, LLC

Decatur, GA 30033, United States, LLC

Generation Program - Deerfield Beach - Quantam Laboratories - Memory Center

Deerfield Beach, FL 33064, United States
Quantam Laboratories - Memory Center

Generation Program - Delray Beach - Brain Matters Research

Delray Beach, FL 33445, United States
Brain Matters Research

Generation Program - Durham - Duke University

Durham, NC 27705, United States
Duke University

Generation Program - East Providence - Rhode Island Mood & Memory Research Inst.

East Providence, RI 02914, United States
Rhode Island Mood and Memory Research Institute

Generation Program - East Syracuse - Clarity Clinical Research, LLC

East Syracuse, NY 13057, United States
Clarity Clinical Research, LLC

Generation Program - Elk Grove Village - Alexian Brothers Medical Center

Elk Grove Village, IL 60007, United States
Alexian Brothers Medical Center

Generation Program - Greensboro - Triad Clinical Trials

Greensboro, NC 27410, United States
Triad Clinical Trials