FIT-AD SMART Trial - Phoenix, AZ

FIT-AD SMART Trial is a 12-month study that is testing the impact of various exercise types on cognitive and physical outcomes in older

adults with early-stage Alzheimer's disease. A study partner is required to report on quality-of-life measures.

Arizona State University researchers seek to discover the most effective approaches to slowing

cognitive decline in people with early stage Alzheimer's, possibly through exercise.

Those interested will undergo a 4-step screening process that involves a phone interview, an in-person interview that includes memory and thinking tests, medical clearance, an exercise stress test as well as an MRI brain scan.

Those who are fully eligible and enroll in the study will complete the baseline cognitive, physical, and blood assessments. Participants will then be randomly assigned to an aerobic cycling or stretch exercise group and complete exercise sessions 3 times per week for 3 months. Participants are retested for the cognitive, physical, and blood

assessments at 3 months. Those within the aerobic exercise group have the possibility of remaining in their aerobic cycling group or being re-randomly assigned to either a high-intensity interval cycling training or a combined strength building and aerobic cycling group. All participants will complete an additional 3 months of exercise training in their groups 3 times per week.

Participants will undergo the cognitive, physical, and blood assessments again at the 6-, 9-, and 12-month time points.

Participants will also be asked to complete monthly follow up questions that can be administered over the phone or in person.

Study partner/caregiver questionnaires will be completed at baseline, 3, 6, 9, and 12 months.

Participation is voluntary.