Effects of Donepezil HCl on Task-Activated fMRI Brain Activation - Cleveland, OH

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Effects of Donepezil HCl on Task-Activated fMRI Brain Activation - Cleveland, OH


Study Status:
Recruiting
Age:
60 to 80
Duration:
7 months
Study Type:
Prevention Studies
Studies for People without Memory Impairment

Eligibility Requirements:

Men and women who:

  • Are between 60-80 years of age
  • Are in good general health
  • Have had a 1st or 2nd degree relative diagnosed with Alzheimer’s disease
  • Have not been diagnosed with any memory problems
  • Are able to undergo an MRI

About the Study:

The purpose of this study is to determine if functional magnetic resonance imaging (fMRI) can detect changes in the brain caused by the drug donepezil HCL in patients at risk for developing Alzheimer’s disease. This drug has been approved by the U.S. Food and Drug Administration (FDA) for use in patients diagnosed with Alzheimer’s disease to treat mild to moderate memory problems.

The investigators in this study are interested only in the sensitivity of fMRI to detect these brain changes and are not studying the effectiveness of the drug on dementia or memory loss symptoms. 

Purpose:

The purpose of this study is to determine if functional magnetic resonance imaging (fMRI) can detect changes in the brain caused by the drug donepezil HCL in patients at risk for developing Alzheimer’s disease.

What is Involved:

Participation will require at least 9 visits over approximately 7-8 months and will involve:

  • Taking either the study drug or a placebo pill - A placebo pill looks like the study drug but does not contain any medication
  • Blood draws (2)
  • Genetic testing and counseling for the APOE e4 allele
  • MRI scans (2)
  • Comprehensive evaluation of memory function
  • Financial compensation and parking validation for each visit
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