You or a loved one has noticed a memory impairment
You are 50-80 years old
You are a native English speaker
You are right-handed
You don’t have a history of neurological and psychiatric disease, fainting, Alzheimer disease, or seizure
You don’t have electrical implant
You don’t have a cochlear implant
You don’t have recent drug withdrawal
You don’t have any implanted metal in your body
You are willing to attend study visits at the University of Arizona in Tucson, AZ
About the Study:
This study involves the integration of two emerging technologies.
1) Magnetic Resonance Imaging (MRI) – this is similar to any MRI prescribed by your doctor.
2) Transcranial Magnetic Stimulation (TMS) – this is a non-invasive method of “brain stimulation”. It involves placing a magnetic coil on the surface of your head. The magnetic coil is about the same strength as MRI. When this coil is turned on and off quickly, it can excite the neurons in the brain tissue located directly under the coil.
When using TMS, researchers are able to excite the brain tissue underneath the magnetic coil – and, essentially, this “turns on” a pathway of communication. This study will use TMS to stimulate the brain’s memory center to study whether this is a viable approach to improve memory and/or protect against memory decline. Brain imaging techniques, neuropsychological assessments, and observations from body worn devices before and after the brain stimulation protocol will be used to study how the brain responds.
What is Involved:
Component 1a: If you decide to participate, you will be asked to complete 7 testing sessions in 7 weeks, which will each take approximately 1 to 2 hours. *Optional* additional 6 sessions may be applied.
Component 1b: If you are eligible after Component 1a, you will be asked to receive 30 intervention sessions for three different protocols (10 sessions for each). Each intervention will be around half hour and each outcome measurement will take another one hour.
Component 2: If you are eligible, you will be asked to receive daily intervention sessions for up to 4 consecutive weeks, which will be quicker study visits lasting less than 30 minutes (notably, these will consist of less than 5 minutes of stimulation).
Component 3: There will be another 4 testing sessions to evaluate treatment effects. They will be scheduled at the beginning, at the end of 2-week treatment, at the end of 4-week treatment, and 3 months after the end of 4-week treatment sessions. You don’t need to come to the laboratory during the weekends.
All sessions will take place in the Biosciences Research Laboratories (BSRL) Building (1230 N. Cherry Ave., Tucson, AZ 85721).
An Institutional Review Board responsible for human subjects research at The University of Arizona reviewed this research project and found it to be acceptable, according to applicable state and federal regulations and University policies designed to protect the rights and welfare of participants in research.