AHEAD Study - Multiple Sites

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AHEAD Study - Multiple Sites


Age:
55 to 80
Duration:
4 years
Visits:
Varies
Study Type:
Prevention Studies
Studies for People without Memory Impairment

Eligibility Requirements:

To be eligible for the AHEAD Study, you must:

  • be between the ages of 55 to 80 years 
    • if you are age 55 to 64, you also need to have one of the following additional risk factors:
      • first degree relative diagnosed with dementia onset before age 75,

OR

  • known to have at least 1 copy of the APOE4 gene,

OR

  • known to have elevated brain amyloid based on a prior PET brain scan or CSF (lumbar puncture / spinal tap) testing
  • not been diagnosed with Alzheimer’s disease or another dementia
  • have elevated or intermediate levels of amyloid in their brains determined by brain imaging as part of the study
  • agree to approximately a 4-year commitment in the study involving in-person and telephone visits with study researchers every two to four weeks
  • have a study partner, either close relative or friend, willing to attend some of the study visits
  • able to get an MRI and PET scans

Participants will be compensated for their time.

About the Study:

The AHEAD Study is a new trial aiming to prevent Alzheimer’s disease. It is evaluating whether an investigational treatment (BAN2401 (lecanemab)) can lower the amount of amyloid in the brain and how that impacts decline in memory loss due to Alzheimer’s.


Studies have shown that changes caused by Alzheimer’s occur in the brain many years before a person shows symptoms of the disease. 

Purpose:

The purpose of the AHEAD Study is to determine whether intervention with the investigational anti-amyloid treatment, BAN2401 (lecanemab), can slow the earliest brain changes associated with Alzheimer’s disease and help to prevent the associated memory loss, especially if started early, before symptoms are clinically apparent. The AHEAD Study will help researchers understand what early Alzheimer’s disease changes in the brain, such as specific levels of amyloid, detected with imaging and other biomarker tests, are associated with cognitive decline.  


The AHEAD Study may also help researchers understand why some groups are at increased risk and find the most appropriate treatment for all individuals.

What is Involved:

If you qualify for the AHEAD Study, you will receive the study treatment (investigational treatment [BAN2401 (lecanemab)] or placebo) intravenously (IV) every other week or monthly, depending on whether you are in AHEAD-3 or AHEAD-45. 


Please see study website for additional information: aheadstudy.org

 SELECT A SITE BELOW 

United States

AHEAD Study - New York, NY - Mt Sinai School of Medicine

New York, NY 10029, United States
Mt Sinai School of Medicine

AHEAD Study - Newport Beach, CA - Hoag Neurological Institute

Newport Beach, CA 92663, United States
Hoag Neurological Institute

AHEAD Study - Norfolk, VA - Eastern Virginia Medical School

Norfolk, VA 23510, United States
Eastern Virginia Medical School

AHEAD Study - Norristown, PA - Keystone Clinical Studies, LLC

Plymouth Meeting, PA 19462, United States
Keystone Clinical Studies, LLC

AHEAD Study - Ocala, FL - Renstar Medical Research

Ocala, FL 34471, United States
Renstar Medical Research

AHEAD Study - Orlando, FL - Synexus Clinical Research

Orlando, FL 32806, United States
Synexus Clinical Research - Orlando

AHEAD Study - Palo Alto, CA - Stanford Center for Memory Disorders

Palo Alto, CA 94304, United States
Stanford Center for Memory Disorders

AHEAD Study - Philadelphia, PA - University of Pennsylvania (3400)

Philadelphia, PA 19104, United States
University of Pennsylvania

AHEAD Study - Phoenix, AZ - Banner Alzheimer's Institute

Phoenix, AZ 85006, United States
Banner Alzheimer's Institute

AHEAD Study - Pittsburg, PA - University of Pittsburg

Pittsburgh, PA 15213, United States
University of Pittsburgh

AHEAD Study - Plymouth, MA - Donald S. Marks., MD., P.C

Plymouth, MA 02360, United States
Donald S. Marks., MD., P.C

AHEAD Study - Port Orange, FL - Progressive Medical Research

Port Orange, FL 32127, United States
Progressive Medical Research

AHEAD Study - Portland, OR - Oregon Health and Science University - Portland

Portland, OR 97239, United States
Oregon Health and Science University - Portland

AHEAD Study - Portland, OR - Summit Research Network

Portland, OR 97210, United States
Summit Research Network

AHEAD Study - Providence, RI - Butler Hospital Memory and Aging Program

Providence, RI 02906, United States
Butler Hospital Memory and Aging Program

AHEAD Study - Providence, RI - Rhode Island Hospital

Providence, RI 02903, United States
Rhode Island Hospital - Providence

AHEAD Study - Richmond, VA - National Clinical Research Inc

Richmond, VA 23294, United States
National Clinical Research Inc.

AHEAD Study - Rochester, MN - Mayo Clinic

Rochester, MN 55905, United States
Mayo Clinic, Rochester

AHEAD Study - Rochester, NY - University of Rochester Medical Center

Rochester, NY 14620, United States
University of Rochester Medical Center 315

AHEAD Study - San Antonio, TX - University of Texas Health Sciences Center of SA

San Antonio, TX 78229, United States
University of Texas Health Sciences Center of San Antonio

AHEAD Study - San Diego, CA - Sharp Neurocognitive Research Center

San Diego, CA 92123, United States
Sharp Neurocognitive Research Center

AHEAD Study - San Francisco, CA - University of California, San Francisco

San Francisco, CA 94158, United States
University of California, San Francisco

AHEAD Study - Seattle, WA - University of Washington

Seattle, WA 98104, United States
University of Washington

AHEAD Study - St. Louis, MO - Washington University

St. Louis, MO 63110, United States
Washington University 600

AHEAD Study - Sun City, AZ - Banner Sun Health Research Institute

Sun City, AZ 85351, United States
Banner Sun Health Research Institute

AHEAD Study - Tampa, FL - University of South Florida Health Byrd Alz Inst.

Tampa, FL 33613, United States
University of South Florida - Health Byrd Alzheimer Institute

AHEAD Study - The Villages, FL - Synexus Clinical Research

The Villages, FL 32162, United States
Synexus Clinical Research – The Villages

AHEAD Study - Toms River, NJ - Advanced Memory Research Institute (AMRI)

Toms River, NJ 08755, United States
Advanced Memory Research Institute (AMRI

AHEAD Study - Tulsa, OK - Central States Research, LLC

Tulsa, OK 74136, United States
Central States Research

AHEAD Study - Wake Forest, NC - Wake Forest University Health Sciences

Winston-Salem, NC 27157, United States
Wake Forest University Health Sciences