AHEAD Study - Multiple Sites

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AHEAD Study - Multiple Sites

55 to 80
4 years
Study Type:
Prevention Studies
Studies for People without Memory Impairment

Eligibility Requirements:

To be eligible for the AHEAD Study, you must:

  • be between the ages of 55 to 80 years 
    • if you are age 55 to 64, you also need to have one of the following additional risk factors:
      • first degree relative diagnosed with dementia onset before age 75,


  • known to have at least 1 copy of the APOE4 gene,


  • known to have elevated brain amyloid based on a prior PET brain scan or CSF (lumbar puncture / spinal tap) testing
  • not been diagnosed with Alzheimer’s disease or another dementia
  • have elevated or intermediate levels of amyloid in their brains determined by brain imaging as part of the study
  • agree to approximately a 4-year commitment in the study involving in-person and telephone visits with study researchers every two to four weeks
  • have a study partner, either close relative or friend, willing to attend some of the study visits
  • able to get an MRI and PET scans

Participants will be compensated for their time.

About the Study:

The AHEAD Study is a new trial aiming to prevent Alzheimer’s disease. It is evaluating whether an investigational treatment (BAN2401 (lecanemab)) can lower the amount of amyloid in the brain and how that impacts decline in memory loss due to Alzheimer’s.

Studies have shown that changes caused by Alzheimer’s occur in the brain many years before a person shows symptoms of the disease. 


The purpose of the AHEAD Study is to determine whether intervention with the investigational anti-amyloid treatment, BAN2401 (lecanemab), can slow the earliest brain changes associated with Alzheimer’s disease and help to prevent the associated memory loss, especially if started early, before symptoms are clinically apparent. The AHEAD Study will help researchers understand what early Alzheimer’s disease changes in the brain, such as specific levels of amyloid, detected with imaging and other biomarker tests, are associated with cognitive decline.  

The AHEAD Study may also help researchers understand why some groups are at increased risk and find the most appropriate treatment for all individuals.

What is Involved:

If you qualify for the AHEAD Study, you will receive the study treatment (investigational treatment [BAN2401 (lecanemab)] or placebo) intravenously (IV) every other week or monthly, depending on whether you are in AHEAD-3 or AHEAD-45. 

Please see study website for additional information: aheadstudy.org


United States

AHEAD Study - Ann Arbor, MI - University of Michigan

Ann Arbor, MI 48109, United States
University of Michigan

AHEAD Study - Atlanta, GA - Emory University

Atlanta, GA 30329, United States
Emory University AHEAD

AHEAD Study - Baltimore, MD - Johns Hopkins University Medical Center

Baltimore, MD 21224, United States
Johns Hopkins University

AHEAD Study - Birmingham, AL - University of Alabama Birmingham

Birmingham, AL 35233, United States
University Alabama Birmingham

AHEAD Study - Boston, MA - Boston University - Alzheimer's Disease Center

Boston, MA 02118, United States
Boston University - Alzheimer's Disease Center

AHEAD Study - Boston, MA - Brigham and Women's Hospital

Boston, MA 02115, United States
Brigham and Women's Hospital

AHEAD Study - Chicago, IL - Rush University

Chicago, IL 60612, United States
Rush University

AHEAD Study - Cleveland, OH - Cleveland Clinic Lou Ruvo Center

Cleveland, OH 44195, United States
Cleveland Clinic Lou Ruvo Center for Brain Health

AHEAD Study - Coral Gables, FL - Advanced Clinical Research Network

Miami, FL 33135, United States
Advanced Clinical Research Network

AHEAD Study - Delray Beach, FL - Brain Matters Research

Delray Beach, FL 33445, United States
Brain Matters Research

AHEAD Study - Durham, NC - Duke Health Center

Durham, NC 27705, United States
Duke University - Duke Health Center

AHEAD Study - Fort Worth, TX - University of North Texas Health Sciences

Fort Worth, TX 76107, United States
University of North Texas

AHEAD Study - Houston, TX - Baylor College of Medicine

Houston, TX 77030, United States
Baylor College of Medicine

AHEAD Study - Irvine, CA - University of California, Irvine - 1100

Irvine, CA 92697, United States
University of California, Irvine

AHEAD Study - Jacksonville, FL - Mayo Clinic

Jacksonville, FL 32224, United States
Mayo Clinic - Jacksonville

AHEAD Study - Los Angeles, CA - University of Southern California

Los Angeles, CA 90033, United States
University of Southern California

AHEAD Study - Miami, FL - Wien Center for Clinical Research

Miami Beach, FL 33140, United States
Wien Center for Clinical Research

AHEAD Study - Nashville, TN - Vanderbilt University Medical Center

Nashville, TN 37212, United States
Vanderbilt University Medical Center

AHEAD Study - New Haven, CT - Yale University School of Medicine

New Haven, CT 06510, United States
Yale University School of Medicine

AHEAD Study - Norfolk, VA - Eastern Virginia Medical School

Norfolk, VA 23510, United States
Eastern Virginia Medical School

AHEAD Study - Orlando, FL - K2 Medical Research, LLC

Orlando, FL 32751, United States
K2 Medical Research

AHEAD Study - Orlando, FL - Synexus Clinical Research

Orlando, FL 32806, United States
Synexus Clinical Research - Orlando

AHEAD Study - Philadelphia, PA - University of Pennsylvania (3400)

Philadelphia, PA 19104, United States
University of Pennsylvania

AHEAD Study - Phoenix, AZ - Banner Alzheimer's Institute

Phoenix, AZ 85006, United States
Banner Alzheimer's Institute

AHEAD Study - Portland, OR - Oregon Health and Science University - Portland

Portland, OR 97239, United States
Oregon Health and Science University - Portland

AHEAD Study - Portland, OR - Summit Research Network

Portland, OR 97210, United States
Summit Research Network

AHEAD Study - Providence, RI - Rhode Island Hospital

Providence, RI 02903, United States
Rhode Island Hospital - Providence

AHEAD Study - Richmond, VA - National Clinical Research Inc

Richmond, VA 23294, United States
National Clinical Research Inc.

AHEAD Study - Rochester, MN - Mayo Clinic

Rochester, MN 55905, United States
Mayo Clinic, Rochester

AHEAD Study - Rochester, NY - University of Rochester Medical Center

Rochester, NY 14620, United States
University of Rochester Medical Center 315