The DIAGNOSE CTE Study

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The DIAGNOSE CTE Study


New York University Langone Medical Center - Neurology and Concussion Center

240 East 38th Street
20th Floor
New York NY 10016
United States


Study Status:
Recruiting
Age:
45 to 74
Study Type:
Observational Studies
I'm interested in participating in this study

Next Steps

For more information or to find out if you are eligible for the research project, please contact: 

Taylor Platt, Recruitment Coordinator
Tel: 617-414-1193
Email: Diagnose@Bu.Edu
 


Eligibility Requirements

This study is enrolling men, ages 45-74, from one of the following 3 groups:

Former NFL Players:

  • Who played three or more seasons in the NFL 

Former College Football Players:

  • Who played three or more seasons of varsity football at the college level
  • Who never played organized contact sports after college 

Healthy Controls:

  • Who have NO history of participation in organized contact sports
  • Who are NOT diagnosed with brain disorders including dementia and depression
  • Who do NOT have significant problems with memory, thinking, mood, or behavior

About The Study:

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative brain disease associated with repetitive hits to the head, such as those experiences in football and other contact sports. Currently, CTE can only be diagnosed after death. The major goal of this research project is to develop methods of diagnosing CTE during life, so interventions can be developed to help those diagnosed with the disease.

Purpose

Goals of the DIAGNOSE CTE Research Project:

  • To collect and analyze neuroimaging and fluid biomarkers for the detection of CTE during life.
  • To characterize the clinical presentation of CTE.
  • To examine the progression of CTE over a three year period.
  • To refine and validate diagnostic criteria for the clinical diagnosis of CTE.
  • To investigate genetic and head impact exposure risk factors for CTE.
  • To share project data with researchers across the country and abroad in order to expedite growth in our understanding and treatment of this disease.

The ultimate goal is to be able to prevent and treat CTE and other long term consequences of repetitive head impacts in athletes, military personnel, and others.

What Is Involved:

A three day visit to one of the four study sites for: 

  • A thorough medical history and neurological exam 
  • A Magnetic Resonance Imaging (MRI) scan of your brain 
  • Collection of blood and saliva samples 
  • A spinal tap (also called a lumbar puncture) so we can collect fluid from your spinal column 
  • Two Positron Emission Tomography (PET) scans to detect if there are elevations of specific proteins in your brain.
  • Completion of questionnaires on your mood and behavior 
  • A set of standardized tests of your memory and other cognitive skills 

All travel expenses are covered. In addition, participants may receive compensation.
 


Location Information:

New York University Langone Medical Center - Neurology and Concussion Center

240 East 38th Street
20th Floor
New York NY 10016
United States

I'm interested in participating in this study

Next Steps

For more information or to find out if you are eligible for the research project, please contact: 

Taylor Platt, Recruitment Coordinator
Tel: 617-414-1193
Email: Diagnose@Bu.Edu