Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Multiple Sites

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Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Multiple Sites


Eligibility Requirements

Like most clinical trials, the A4 study has very specific eligibility requirements. You may be eligible to join the A4 study if you:

  • Are 65 to 85 years old
  • Have normal thinking and memory abilities
  • Have an A4 study partner – someone who has at least weekly contact with you who can answer questions once a year
  • Are willing and able to receive IV infusions of the investigational treatment or placebo for 36 months (36 monthly infusions); all A4 participants must be willing and able to participate in all required procedures for the duration of the A4 study.

Are willing to have your health monitored throughout the study using assessments such as:

  • Memory and thinking tests
  • ECGs (a look at your heart)
  • PET scan (a way to look for the plaques thought to be associated with AD)
  • MRI scans (a way to take a picture of your brain)
  • Blood and urine tests

About The Study:

The A4 study invites older individuals (ages 65-85) who have normal thinking and memory function but who may be at risk for memory loss due to Alzheimer’s disease, but have no outward signs of the disease to participate in the study. The study seeks to enroll 1,000 adults who have an “elevated” level of amyloid plaque in their brain. Physicians and researchers will use an imaging test called a PET scan to determine whether a potential participant has evidence of this plaque buildup. People who do not show evidence of elevated amyloid in their brains will not be able to participate, but may be asked to participate in a separate study. This group will not receive the investigational drug or placebo (i.e., an inactive substance designed to mimic the appearance of a drug), but will complete the same memory tests every six months to compare changes in cognition over time.

Purpose

The purpose of the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study (the "A4 study" for short) is to test whether a new investigational treatment, called an amyloid antibody, can slow memory loss caused by Alzheimer’s disease. Amyloid is a protein normally produced in the brain that can build up in older people, forming amyloid plaque deposits. Scientists believe this buildup of deposits may play a key role in the eventual development of Alzheimer’s disease-related memory loss. The overall goal of the A4 study is to test whether decreasing amyloid with antibody investigational treatment can help slow the memory loss associated with amyloid buildup in some people.

What Is Involved:

The A4 study lasts for three years, and participants will be required to visit the clinical research site once a month. Participants will be assigned at random to receive either the investigational drug or a placebo and will be monitored over the course of the three years. All clinical studies, including the A4 study, may involve some risks associated with participation. If you are considering participating in A4, you will have detailed discussions with physicians and research staff regarding the investigational treatment and other aspects of the A4 study.
 SELECT A SITE BELOW 
1.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Amherst

Amherst, NY 14226, US
Dent Neurologic Institute
2.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Ann Arbor

Ann Arbor, MI 48105, US
University of Michigan, Ann Arbor
3.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Atlanta

Atlanta, GA 30329, US
Emory University
4.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Baltimore

Baltimore, MD 21224, US
Johns Hopkins University
5.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Beachwood

Beachwood, OH 44122, US
Case Western Reserve University
6.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Birmingham

Birmingham, AL 35294, US
University of Alabama at Birmingham
7.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Boston

Boston, MA 02115, US
Brigham and Women's Hospital
8.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Boston University

Boston, MA 02118, US
Boston University
9.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Charleston

Charleston, SC 29401, US
Roper St. Francis Hospital
10.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Dallas

Dallas, TX 75390, US
University of Texas, Southwestern Medical Center at Dallas
11.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Fairway

Fairway, KS 66205, US
University of Kansas Alzheimer's Disease Center
12.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Georgetown

Washington D.C., DC 20052, US
Georgetown University
13.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Houston

Houston, TX 77030, US
Baylor College of Medicine
14.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Howard

Washington D.C., 20060, US
Howard University
15.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Indianapolis

Indianapolis, IN 46202, US
Indiana University Health Physicians - Neurology
16.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Iowa City

Iowa City, IA 52242, US
University of Iowa
17.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Irvine

Orange, CA 92868, US
University of California, Irvine - Neuropsychiatric Center
18.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Jacksonville

Jacksonville, FL 32224, US
Mayo Clinic - Jacksonville
19.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - La Jolla

La Jolla, CA 92037, US
University of California, San Diego - La Jolla
20.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Las Vegas

Las Vegas, NV 89106, US
Cleveland Clinic Lou Ruvo Center for Brain Health
21.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Lexington

Lexington, KY 40508, US
University of Kentucky - Sanders-Brown Center on Aging
22.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Madison

Madison, WI 53792, US
University of Wisconsin
23.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Miami Beach

Miami Beach, FL 33149, US
Wien Center for Clinical Research
24.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Mount Sinai

New York, NY 10029, US
Mount Sinai School of Medicine
25.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Northwestern

Chicago, IL 60611, US
Northwestern University
26.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Omaha

Omaha, NE 68198, US
University of Nebraska Medical Center
27.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Orangeburg

Orangeburg, NY 10962, US
Nathan Kline Institute for Psychiatric Research
28.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Parkwood Hospital

London, ON N6C 0A7, CA
Parkwood Hospital
29.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Philadelphia

Philadelphia, PA 19104, US
University of Pennsylvania
30.

Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) - Phoenix

Phoenix, AZ 85006, US
Banner Alzheimer's Institute